{"id":16917,"date":"2024-01-11T09:31:22","date_gmt":"2024-01-11T17:31:22","guid":{"rendered":"https:\/\/www.golighthouse.com\/en\/?post_type=applications&#038;p=16917"},"modified":"2025-11-10T11:08:47","modified_gmt":"2025-11-10T19:08:47","slug":"continuous-microbial-monitoring","status":"publish","type":"applications","link":"https:\/\/www.golighthouse.com\/en\/applications\/continuous-microbial-monitoring\/","title":{"rendered":"Continuous Microbial Monitoring"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"16917\" class=\"elementor elementor-16917\" data-elementor-post-type=\"applications\">\n\t\t\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-9704ea4 e-con-full e-flex e-con e-parent\" data-id=\"9704ea4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3ad7b81 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"3ad7b81\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Continuous Microbial Monitoring<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bde8ea elementor-pagination-type-bullets elementor-arrows-position-inside elementor-pagination-position-outside elementor-widget elementor-widget-n-carousel\" data-id=\"9bde8ea\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;carousel_items&quot;:[{&quot;slide_title&quot;:&quot;Slide #1&quot;,&quot;_id&quot;:&quot;de1b3b8&quot;},{&quot;slide_title&quot;:&quot;Slide #2&quot;,&quot;_id&quot;:&quot;a14b9fe&quot;}],&quot;slides_to_show&quot;:&quot;1&quot;,&quot;slides_to_show_tablet&quot;:&quot;2&quot;,&quot;slides_to_show_mobile&quot;:&quot;1&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;infinite&quot;:&quot;yes&quot;,&quot;speed&quot;:500,&quot;offset_sides&quot;:&quot;none&quot;,&quot;arrows&quot;:&quot;yes&quot;,&quot;pagination&quot;:&quot;bullets&quot;,&quot;image_spacing_custom&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;image_spacing_custom_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;image_spacing_custom_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"nested-carousel.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-n-carousel swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Carousel\" dir=\"ltr\">\n\t\t\t<div class=\"swiper-wrapper\" aria-live=\"off\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" data-slide=\"1\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"1 of 2\">\n\t\t\t\t\t\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-88a1777 e-flex e-con-boxed e-con e-child\" data-id=\"88a1777\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-26e4526 elementor-widget elementor-widget-text-editor\" data-id=\"26e4526\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u201cAnnex 1 provides general guidance that should be used in the design and control of facilities, equipment, systems and procedures used for the manufacture of all sterile products applying the principles of Quality Risk Management (QRM), to ensure that microbial, particulate and endotoxin\/pyrogen contamination is prevented in the final product\u201d.\u200b<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" data-slide=\"2\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"2 of 2\">\n\t\t\t\t\t\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-2f08cd0 e-flex e-con-boxed e-con e-child\" data-id=\"2f08cd0\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1d007a2 elementor-widget elementor-widget-text-editor\" data-id=\"1d007a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Continuous viable air monitoring in grade A (e.g. air sampling or settle plates) should be undertaken for the full duration of critical processing, including equipment (aseptic setup) assembly and critical processing. A similar approach should be considered for Grade B cleanrooms based on the risk of impact on the aseptic processing. The monitoring should be performed in such a way that all interventions, transient events and any system deterioration would be captured and any risk caused by interventions of the monitoring operations be avoided.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-prev\" role=\"button\" tabindex=\"0\" aria-label=\"Previous\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-eicon-chevron-left\" viewBox=\"0 0 1000 1000\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M646 125C629 125 613 133 604 142L308 442C296 454 292 471 292 487 292 504 296 521 308 533L604 854C617 867 629 875 646 875 663 875 679 871 692 858 704 846 713 829 713 812 713 796 708 779 692 767L438 487 692 225C700 217 708 204 708 187 708 171 704 154 692 142 675 129 663 125 646 125Z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-next\" role=\"button\" tabindex=\"0\" aria-label=\"Next\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-eicon-chevron-right\" viewBox=\"0 0 1000 1000\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M696 533C708 521 713 504 713 487 713 471 708 454 696 446L400 146C388 133 375 125 354 125 338 125 325 129 313 142 300 154 292 171 292 187 292 204 296 221 308 233L563 492 304 771C292 783 288 800 288 817 288 833 296 850 308 863 321 871 338 875 354 875 371 875 388 867 400 854L696 533Z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t\t\t\t<div class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-8989040 e-con-full e-flex e-con e-parent\" data-id=\"8989040\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-db2fc08 e-con-full e-flex e-con e-child\" data-id=\"db2fc08\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-19d4ae9 e-flex e-con-boxed e-con e-child\" data-id=\"19d4ae9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;slideshow&quot;,&quot;background_slideshow_gallery&quot;:[{&quot;id&quot;:16921,&quot;url&quot;:&quot;https:\\\/\\\/www.golighthouse.com\\\/en\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/microbial_monitoring_800x600-e1742247732142.jpg&quot;},{&quot;id&quot;:16922,&quot;url&quot;:&quot;https:\\\/\\\/www.golighthouse.com\\\/en\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/microbial_monitoring2_800x600-e1742247718258.jpg&quot;}],&quot;jet_parallax_layout_list&quot;:[],&quot;background_slideshow_loop&quot;:&quot;yes&quot;,&quot;background_slideshow_slide_duration&quot;:5000,&quot;background_slideshow_slide_transition&quot;:&quot;fade&quot;,&quot;background_slideshow_transition_duration&quot;:500}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a7331ac elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"a7331ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16171f5 elementor-widget elementor-widget-heading\" data-id=\"16171f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Microbial Monitoring Tools<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-802d1c6 e-grid e-con-boxed e-con e-child\" data-id=\"802d1c6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-10421d0 elementor-widget elementor-widget-image\" data-id=\"10421d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.golighthouse.com\/en\/microbial-samplers\/activecount\/\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/b_ActiveCount100H_Screen_Image_Handle_down3-1.jpg\" class=\"attachment-large size-large wp-image-16923\" alt=\"ActiveCount100H\" srcset=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/b_ActiveCount100H_Screen_Image_Handle_down3-1.jpg 1000w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/b_ActiveCount100H_Screen_Image_Handle_down3-1-300x300.jpg 300w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/b_ActiveCount100H_Screen_Image_Handle_down3-1-150x150.jpg 150w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/b_ActiveCount100H_Screen_Image_Handle_down3-1-768x768.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-723909c elementor-widget elementor-widget-image\" data-id=\"723909c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.golighthouse.com\/en\/airborne-particle-counters\/apex-remote\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"600\" height=\"650\" src=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/ApexR5.png\" class=\"attachment-large size-large wp-image-16924\" alt=\"\" srcset=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/ApexR5.png 600w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/ApexR5-277x300.png 277w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef692b1 elementor-widget elementor-widget-image\" data-id=\"ef692b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"515\" height=\"387\" src=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/MicrosoftTeams-image-99.png\" class=\"attachment-large size-large wp-image-16925\" alt=\"\" srcset=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/MicrosoftTeams-image-99.png 515w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/MicrosoftTeams-image-99-300x225.png 300w\" sizes=\"(max-width: 515px) 100vw, 515px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2f02caa elementor-widget elementor-widget-image\" data-id=\"2f02caa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.golighthouse.com\/en\/microbial-samplers\/activecountr\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"455\" src=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2023\/04\/b_RAC_System_Impactor-1.jpg\" class=\"attachment-large size-large wp-image-13552\" alt=\"RAC system impactor\" srcset=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2023\/04\/b_RAC_System_Impactor-1.jpg 640w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2023\/04\/b_RAC_System_Impactor-1-300x213.jpg 300w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b40ad41 elementor-widget elementor-widget-image\" data-id=\"b40ad41\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.golighthouse.com\/en\/microbial-samplers\/activecountr\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"812\" src=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2023\/04\/b_Remote_Active_Count_CUTOUT_276_k.jpg\" class=\"attachment-large size-large wp-image-13551\" alt=\"Remote Active Count\" srcset=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2023\/04\/b_Remote_Active_Count_CUTOUT_276_k.jpg 985w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2023\/04\/b_Remote_Active_Count_CUTOUT_276_k-296x300.jpg 296w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2023\/04\/b_Remote_Active_Count_CUTOUT_276_k-768x780.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-2094d17 e-flex e-con-boxed e-con e-child\" data-id=\"2094d17\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-72804bc e-con-full e-flex e-con e-child\" data-id=\"72804bc\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c540572 elementor-widget elementor-widget-heading\" data-id=\"c540572\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><B>EU GMP Annex 1:<\/B><BR>Elevating Sterile Product Manufacturing Standards<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1720214 elementor-widget elementor-widget-text-editor\" data-id=\"1720214\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Aseptic Sterile Manufacturing. The art of performing a specific sterile manufacturing process within an ultra clean cleanroom environment to ensure that the product\u2019s such as an injectable solution is transported from bulk sterile containers and filled into vials, or syringes or capsules. Ensuring complete sterility of the product.<\/p><p><strong>EU GMP Annex 1 States:<\/strong><br \/><strong>Continuous microbial\u00a0 monitoring in grade A (e.g. air sampling or settle plates) should be undertaken for the full duration of critical processing, including equipment (aseptic setup) assembly and critical processing. A similar approach should be considered for Grade B cleanrooms based on the risk of impact on the aseptic processing. The monitoring should be performed in such a way that all interventions, transient events and any system deterioration would be captured and any risk caused by interventions of the monitoring operations be avoided.<\/strong><\/p><p>How do you meet continuous viable air monitoring? The best way is to understand the technology we use and to select the right <a href=\"https:\/\/www.golighthouse.com\/en\/knowledge-center\/introduction-to-viable-sampling\/\" target=\"_blank\" rel=\"noopener\">viable monitoring solutions<\/a>. Check out the video below to get an idea of how to monitor a BSC using particle counters, active air samplers and settle plates. \u200b<\/p><p>\u200b\u201cAnnex 1 provides general guidance that should be used in the design and control of facilities, equipment, systems and procedures used for the manufacture of all sterile products applying the principles of Quality Risk Management (QRM), to ensure that microbial, particulate and endotoxin\/pyrogen contamination is prevented in the final product\u201d.\u200b<\/p><p><a href=\"https:\/\/www.golighthouse.com\/en\/lws-consultant-services\/\" target=\"_blank\" rel=\"noopener\">\u200bLet us help you understand<\/a> how you can meet Annex1 continuous viable monitoring requirements using existing technology that you may have without breaking the bank or having to revalidate your system.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-46468f2 e-flex e-con-boxed e-con e-child\" data-id=\"46468f2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-adca13f elementor-widget__width-initial elementor-widget elementor-widget-eael-adv-tabs\" data-id=\"adca13f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"eael-adv-tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t        <div data-scroll-on-click=\"no\" data-scroll-speed=\"300\" id=\"eael-advance-tabs-adca13f\" class=\"eael-advance-tabs eael-tabs-vertical eael-tab-auto-active \" data-tabid=\"adca13f\">\n            <div class=\"eael-tabs-nav \">\n                <ul class=\"\" role=\"tablist\">\n                                            <li id=\"strongair-samplingstrong\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"strongair-samplingstrong-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" ><strong>Air Sampling<\/strong><\/span>                                                    <\/li>\n                                            <li id=\"strongaseptic-fillingstrong\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"strongaseptic-fillingstrong-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" ><strong>Aseptic Filling<\/strong><\/span>                                                    <\/li>\n                                            <li id=\"strongbsc-demostrong\" class=\"inactive eael-tab-item-trigger eael-tab-nav-item\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"strongbsc-demostrong-tab\" aria-expanded=\"false\">\n                            \n                            \n                            \n                                                            <span class=\"eael-tab-title title-after-icon\" ><strong>BSC Demo<\/strong><\/span>                                                    <\/li>\n                    \n                                  <\/ul>\n            <\/div>\n            \n            <div class=\"eael-tabs-content\">\n\t\t        \n                    <div id=\"strongair-samplingstrong-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"strongair-samplingstrong-tab\">\n\t\t\t\t        <p>Active air sampling during aseptic processing is a critical requirement in Grade A cleanrooms. Key considerations include the physical and biological efficiencies of air samplers, appropriate flowrates, and HEPA-filtered exhausts. The goal is to maintain an environment with zero CFUs<\/p>                    <\/div>\n\t\t        \n                    <div id=\"strongaseptic-fillingstrong-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"strongaseptic-fillingstrong-tab\">\n\t\t\t\t        <p>\t\t<div data-elementor-type=\"section\" data-elementor-id=\"16945\" class=\"elementor elementor-16945\" data-elementor-post-type=\"elementor_library\">\n\t\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-a7ca338 e-flex e-con-boxed e-con e-parent\" data-id=\"a7ca338\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5f5ae9a elementor-widget elementor-widget-video\" data-id=\"5f5ae9a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=WmMkGZTL9SY&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/p>                    <\/div>\n\t\t        \n                    <div id=\"strongbsc-demostrong-tab\" class=\"clearfix eael-tab-content-item inactive\" data-title-link=\"strongbsc-demostrong-tab\">\n\t\t\t\t        <p>\t\t<div data-elementor-type=\"section\" data-elementor-id=\"16941\" class=\"elementor elementor-16941\" data-elementor-post-type=\"elementor_library\">\n\t\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-aead606 e-flex e-con-boxed e-con e-parent\" data-id=\"aead606\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-652bc3c elementor-widget elementor-widget-video\" data-id=\"652bc3c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/Z4POsnIMDjU?si=S2Iovw_OHSLhXLd_&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/p>                    <\/div>\n\t\t                    <\/div>\n        <\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6820a10 elementor-widget elementor-widget-video\" data-id=\"6820a10\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=eorn-mB0djM&quot;,&quot;lazy_load&quot;:&quot;yes&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-c4ecc9b e-con-full e-flex e-con e-parent\" data-id=\"c4ecc9b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-3a1e311 e-flex e-con-boxed e-con e-child\" data-id=\"3a1e311\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5cbb734 elementor-widget elementor-widget-heading\" data-id=\"5cbb734\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><B>Cost Reductions<\/B> on 8 Hour Process<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-b1a9ac4 e-flex e-con-boxed e-con e-parent\" data-id=\"b1a9ac4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-3903468 e-con-full e-flex e-con e-child\" data-id=\"3903468\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0a68e10 elementor-widget elementor-widget-heading\" data-id=\"0a68e10\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">100L\/min Flowrate<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-35c6a40 elementor-widget elementor-widget-image\" data-id=\"35c6a40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"525\" src=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-1024x672.png\" class=\"attachment-large size-large wp-image-16929\" alt=\"\" srcset=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-1024x672.png 1024w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-300x197.png 300w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-768x504.png 768w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-1536x1007.png 1536w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-2048x1343.png 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-949a6f5 elementor-widget elementor-widget-text-editor\" data-id=\"949a6f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Media dish every 10 minutes<\/li><li>48 media dishes every 8 hours<\/li><li>336 per week (7 days)<\/li><li>17472 media dishes per year<\/li><li>$52,416 cost per year<\/li><li>$262,080 per filling line<\/li><li>Labor costs per year $1.7m<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-6d5a0d9 e-con-full e-flex e-con e-child\" data-id=\"6d5a0d9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b1a710 elementor-widget elementor-widget-heading\" data-id=\"7b1a710\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">25L\/min Flowrate<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0340a82 elementor-widget elementor-widget-image\" data-id=\"0340a82\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"525\" src=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-1024x672.png\" class=\"attachment-large size-large wp-image-16929\" alt=\"\" srcset=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-1024x672.png 1024w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-300x197.png 300w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-768x504.png 768w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-1536x1007.png 1536w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-2048x1343.png 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65eec03 elementor-widget elementor-widget-text-editor\" data-id=\"65eec03\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Media dish every 40 minutes<\/li><li>12 media dishes every 8 hours<\/li><li>84 per week (7 days)<\/li><li>4368 media dishes per year<\/li><li>$13,104 cost per year<\/li><li>$65,520 per filling line<\/li><li>Labor costs per year $699k<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-9137a56 e-con-full e-flex e-con e-child\" data-id=\"9137a56\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ff3c598 elementor-widget elementor-widget-heading\" data-id=\"ff3c598\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">10L\/min Flowrate<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8c2bc9c elementor-widget elementor-widget-image\" data-id=\"8c2bc9c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"525\" src=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-1024x672.png\" class=\"attachment-large size-large wp-image-16929\" alt=\"\" srcset=\"https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-1024x672.png 1024w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-300x197.png 300w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-768x504.png 768w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-1536x1007.png 1536w, https:\/\/www.golighthouse.com\/en\/wp-content\/uploads\/2024\/01\/Petri-dish_flow-2048x1343.png 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f854271 elementor-widget elementor-widget-text-editor\" data-id=\"f854271\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Media dish every 100 minutes<\/li><li>5 media dishes every 8 hours<\/li><li>35 per week (7 days)<\/li><li>1820 media dishes per year<\/li><li>$5460 cost per year<\/li><li>$27,300 per filling line<\/li><li>Labor costs per year $291k<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div data-particle_enable=\"false\" data-particle-mobile-disabled=\"false\" class=\"elementor-element elementor-element-c356d9b e-flex e-con-boxed e-con e-parent\" data-id=\"c356d9b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-149bff0 elementor-widget elementor-widget-text-editor\" data-id=\"149bff0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\">If you&#8217;d like to learn more, complete the form below and our team will contact you.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c13d749 elementor-widget elementor-widget-html\" data-id=\"c13d749\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<script type=\"text\/javascript\" id=\"jsFastForms\" src=\"https:\/\/sfapi.formstack.io\/FormEngine\/Scripts\/Main.js?d=ffbDz1IbTzzNdbhm86CBmve88q5F8so_Z8DexMfR2vP2XV5wY3wpp3Gg5ME53QGd\"><\/script>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u201cAnnex 1 provides general guidance that should be used in the design and control of facilities, equipment, systems and procedures used for the manufacture of all sterile products applying the [&hellip;]<\/p>\n","protected":false},"featured_media":17170,"menu_order":0,"template":"elementor_header_footer","format":"standard","applications-taxonomies":[162,164],"class_list":["post-16917","applications","type-applications","status-publish","format-standard","has-post-thumbnail","hentry","applications-taxonomies-activecount","applications-taxonomies-activecountr"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Continuous Microbial Monitoring<\/title>\n<meta name=\"description\" content=\"Continuous microbial\u00a0 monitoring in grade A (e.g. air sampling or settle plates) should be undertaken for the full duration of critical processing, including equipment (aseptic setup) assembly and critical processing.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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